Uptake of 3H-Griseofulvin by Micro-organisms and its Correlation with Sensitivity to Griseofulvin

Uptake of Griseofulvin by the Sensitive Dermatophyte, Microsporum Gypseum.

El-Nakeeb, Moustafa A. (Rutgers, The State University, New Brunswick, N.J.), and J. O. Lampen. Uptake of griseofulvin by the sensitive dermatophyte, Microsporum gypseum. J. Bacteriol. 89:564-569. 1965.-Actively growing cultures of Microsporum gypseum took up large amounts of griseofulvin-(4-methoxy-H(3)) from the medium. Initially, most of the material could be extracted with hot water, but the...

Raynaud's disease treated with griseofulvin.

The patient, a 7-year-old girl, with no previous history of circulatory disorder, developed rubella, and a week later a discoloration of her fingers was noted. The index finger of the right hand became purple and cold and then the index finger of her left hand became similarly affected. Other fingers were soon involved (see Fig.) and by the third week some discoloration of the toes was noticed....

Cardiovascular effects of griseofulvin.

The intravenous administration of griseofulvin in doses of 3.0 mg/kg to 32 anesthetized open-chest dogs produced marked increments (43%) in isometric systolic force measured by a strain gauge. These changes were accompanied by an increase (22%) in heart rate and a decrease (25%) in blood pressure. The effect was unaltered by clamping the blood supply to and from the adrenal glands or by previou...

The chemistry of griseofulvin.

PREPARATION AND OPTIMISATIONOF PALM-BASED LIPID NANOPARTICLES LOADED WITH GRISEOFULVIN

Palm-based lipid nanoparticle formulation loaded with griseofulvin was prepared by hot homogenisation and a solvent-free method. The optimum griseofulvin loaded lipid nanoparticles were prepared via stages of optimisation, such as high pressure homogenisation (HPH) parameters, lipid and surfactant screening and selection of suitable lipid to surfactant ratios; followed by photon correlation stu...